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Updated: Jul 4, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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开发强大的双BET/HDAC抑制剂通过药融合和结构导向优化

Nicolas Bauer1,2, Dimitrios-Ilias Balourdas1,2, Joel R Schneider3,4

  • 1Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.

ACS chemical biology
|January 31, 2024
PubMed
概括

研究人员开发了新型的双马蛋白和额外终端域 (BET) 和激素脱乙酶 (HDAC) 抑制剂,用于困难的癌症. 这些强大的化合物在胰腺癌和NUT中线癌症模型中表现有前途,通过准关键的癌症驱动基因.

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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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