逐步膜招募机动对狗肺体积分布的影响,通过计算机断层扫描进行评估
Ana Flávia Sanchez1, Aline Magalhães Ambrósio1, Ana Carolina B C Fonseca Pinto2
1Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, São Paulo, Brazil.
Frontiers in veterinary science
|January 31, 2024
概括
带有正极呼气压 (PEEP) 的气泡招募机动 (ARM) 在机械通风过程中改善了肺空气. 计算机断层扫描 (CT) 证实了PEEP 20 cmH2O的最佳肺体积分布,没有过度通胀.
科学领域:
- 兽医麻醉学 兽医麻醉学
- 呼吸系统生理学 呼吸系统生理学
- 医疗成像医学成像
背景情况:
- 在麻醉过程中,肺动脉通风是常见的,需要机械通风 (MV).
- 使用带膜招募机动 (ARM) 带有正极呼气压 (PEEP) 用于改善氧化.
- 武器携带风险,如卷外伤,巴罗外伤和电外伤,需要监控.
研究的目的:
- 用计算机断层扫描 (CT) 来评估循序渐进的ARM后的肺体积分布.
- 为了确定最佳的PEEP水平,以实现最大的肺空气,而无需过度通胀.
主要方法:
- 12只狗在麻醉和机械通风下进行了手术.
- 使用增加PEEP水平 (5,10,15,20cmH2O) 应用了逐步的ARM.
- 在每个PEEP级别评估了CT扫描,心血管参数和呼吸机制.
主要成果:
- CT显示ARM增加了肺透气,特别是在依赖区域,与PEEP成比例.
- 在PEEP 10和5cmH2O (下降) 的肺体积仍然明显高于基线.
- 静态合规性在PEEP 10和5cmH2O (下降) 中提高了约40%.
结论:
- 计算机断层扫描显示在PEEP 20 cmH2O时最大的肺气化分布.
- 这种PEEP水平保持了正常变化,但没有引起高通胀.
- 逐步PEEP标配有效地优化了机械通风期间的肺空气.
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