客观测量的体力活动与亚临床心血管疾病之间的关系:系统性审查
Aparna Narendrula1, Ellen Brinza2, Christine Horvat Davey3
1Internal Medicine, NYU Grossman School of Medicine, New York, New York, USA.
BMJ open sport & exercise medicine
|January 31, 2024
概括
身体活动 (PA) 与降低亚临床心血管疾病 (CVD) 有关. 这次审查突出了PAPA的重点.
科学领域:
- 心血管疾病研究研究
- 运动生理学 运动生理学
- 预防性心脏病学 预防性心脏病学
背景情况:
- 身体活动 (PA) 和亚临床心血管疾病 (CVD) 之间的关系需要澄清,以便制定有效的预防策略.
- 亚临床心血管疾病代表疾病的早期阶段,在临床事件出现之前为干预提供了一个窗口.
研究的目的:
- 系统地审查和综合关于客观测量的身体活动与亚临床心血管疾病的各种标志物之间的关联的证据.
- 确定哪些替代结果措施对评估未来心血管疾病预防干预措施最相关.
主要方法:
- 从2000年1月到2023年9月,使用Medline,Embase,CINAHL和Cochrane数据库进行了系统审查.
- 包括专注于成年人群的研究和客观测量PA与亚临床心血管疾病标志物相关的研究,如脚-手腕指数,动脉硬,心动脉病,冠状动脉动脉硬化,内皮功能和心脏结构/功能.
- 使用ROBINS-I和Cochrane偏差风险工具评估了研究质量.
主要成果:
- 大多数68项纳入的研究表明,身体活动和亚临床心血管疾病之间存在反向关系.
- 动脉硬性经常被研究,大多数研究表明,增加PA或减少久坐行为与较少的动脉硬性有关.
- 还观察到PA/减少静坐行为与脚-手腕指数,动脉疾病,内皮功能以及心脏结构/功能变化的积极关联.
结论:
- 这一系统性审查支持身体活动与亚临床心血管疾病之间的反向关联,表明PA对心血管疾病事件的保护作用的机制.
- 研究结果强调了身体活动干预措施在预防心血管疾病方面的重要性.
- 该审查为评估未来预防策略提供了有用的替代结果措施的见解.
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