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放射治疗诱导了血清抗氧化能力的增加,反映了瘤反应

F V Reinema¹, J H A M Kaanders¹, W J M Peeters¹

¹Radiotherapy and OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, The Netherlands.

Clinical and translational radiation oncology

|January 31, 2024

概括

头癌的放射治疗增加了抗氧化剂活性,可能降低了治疗的有效性. 在治疗期间血清抗氧化能力较高可能会预测头部和部状细胞癌患者的治疗结果较差.

科学领域:

在瘤学瘤学.
辐射瘤学辐射瘤学
癌症生物学癌症生物学

背景情况:

放射治疗 (RT) 是治疗头部和部状细胞癌 (HNSCC) 的首要治疗方法.
患者对RT的反应有所不同,可能是由于抗氧化机制抵消RT诱导的氧化损伤.
由RT产生的反应性氧物种 (ROS) 对其治疗效果至关重要.

研究的目的:

调查局部和全身抗氧化剂对RT诱导的ROS反应之间的关系.
确定这些抗氧化剂反应是否与HNSCC.治疗成功相关.

主要方法:

在RT前后,癌细胞和患者瘤活检中的核红素因子2相关因子2 (NRF2) 的免疫光染色.
在RT期间,对HNSCC细胞*in vitro*和患者血清中总抗氧化能力 (TAC) 的分析.

主要成果:

在RT之后,NRF2表达和TAC在HNSCC细胞中增加 *in vitro* .
患者瘤中NRF2表达也增加,与RT期间血清TAC升高相关.
在RT期间血清TAC升高与局部瘤控制降低有关.

结论:

RT诱导NRF2表达,并提高TAC的调节,这可能会降低RT诱导的ROS的疗效.
在RT期间血清TAC水平可以作为HNSCC患者治疗结果的预测生物标志物.

关键词:

抗氧化剂是一种抗氧化剂.头部和部癌症头部和部癌症与NF-E2相关的第2因子 (NRF2)耳鼻喉 (oropharynx) 是一个氧化应激是一种氧化应激.有反应性氧物种的反应性氧物种.头部和部的状细胞癌.

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