阿博特完整PTH的特定年龄参考区间 - - 对临床护理的潜在影响
Tejas Kalaria1, Alexander J Lawson1, Joanne Duffy1
1Clinical Biochemistry, University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2GW, UK.
Journal of the Endocrine Society
|January 31, 2024
概括
本研究为阿博特完整副甲状腺激素 (iPTH) 试验建立了特定年龄的参考间隔. 这些新的间隔对于准确诊断和对甲状腺疾病的管理至关重要.
科学领域:
- 临床化学 临床化学
- 内分泌学 在内分泌学.
- 实验室医学 实验室医学
背景情况:
- 甲状腺激素 (PTH) 测定缺乏标准化,需要方法特定的参考间隔来准确解释.
- 目前没有阿博特完整PTH (iPTH) 试验的年龄相关参考间隔,尽管PTH水平在成年人中随着年龄的增长而增加.
研究的目的:
- 为阿博特完整PTH (iPTH) 试验推导特定年龄的参考间隔.
- 为准确解释成年人群中的 iPTH 结果提供必要的数据.
主要方法:
- 使用了从英格兰中西部实验室 (2015年9月至2022年11月) 获得的非识别血清iPTH结果.
- 包括18岁以上的成年人,其eGFR≥60毫升/分钟,血清25(OH) D>50nmol/L,和正常的/酸盐水平.
- 通过使用与refineR算法间接方法,推导出特定年龄的参考间隔.
主要成果:
- 随着年龄的增长,PTH水平显著增加 (r = 0.093,P < .001).
- 在四个年龄组中建立了特定年龄的IPTH参考间隔:1.6-8.6 pmol/L (18-45岁),1.8-9.5 pmol/L (46-60岁),2.0-11.3 pmol/L (61-80岁) 和2.3-12.3 pmol/L (81-95岁).
- 与男性相比,在女性中观察到更高的PTH水平 (P < .001),尽管由于样本大小,无法确定性别特异的间隔.
结论:
- 成功推导出阿博特 iPTH 试验的特定年龄的参考间隔.
- 预计这些间隔将影响常态血症和二次性甲状腺功能障碍症的诊断和管理.
- 需要进一步的研究来阐明性别和种族对PTH水平的影响.
相关概念视频
01:17Hormones and Bone Tissue
2.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K
01:29Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
01:27Roles of Electrolytes: Calcium and Phosphate
281
Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
The calcium concentration in blood plasma is primarily...
The calcium concentration in blood plasma is primarily...
281
00:59The Parathyroid Glands
2.1K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
2.1K
01:21Skeleton and Calcium Homeostasis
4.5K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
4.5K
01:18Functions of Thyroid Hormones
2.8K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.8K