新辅助化学放射疗法和新辅助化学疗法在食道癌治愈手术中的应用:一个元分析
Mao-Xiu Yuan1,2, Qi-Gui Cai2, Zhen-Yang Zhang3
1The Graduate School, Fujian Medical University, Fuzhou 350000, Fujian Province, China.
World journal of gastrointestinal oncology
|January 31, 2024
概括
新辅助化疗 (nCT) 和化疗放射治疗 (nCRT) 都有助于食道癌的生存. nCT显示出更好的长期存活率和更少的副作用,使其成为局部晚期食道癌的首选选择.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
背景情况:
- 新辅助疗法在食道癌 (EC) 治疗中的作用仍在研究中.
- 局部晚期食道癌 (LAEC) 需要有效的新辅助策略.
研究的目的:
- 为了比较新辅助化学放射治疗 (nCRT) 与新辅助化学疗法 (nCT) 的临床有效性和安全性,用于LAEC.
主要方法:
- 进行了系统的文献综述和元分析.
- 包括到2022年12月发表的比较EC患者nCRT和nCT的研究.
- 搜索了多个数据库,以确保全面的数据检索.
主要成果:
- 新辅助化学辐射疗法 (nCRT) 显示出优异的短期结果,包括更高的完整反应和R0清除率.
- 与nCRT相比,新辅助化疗 (nCT) 显示出更好的5年整体存活率和显著降低心脏和肺部并发症风险.
- 这两种新辅助方法都改善了局部晚期食道癌的生存结果.
结论:
- 在LAEC中,nCRT和nCT都有效提高生存率.
- 由于手术后并发症的发病率较低,nCT提供了优势,这表明某些患者群体的风险益处概况可能更有利.
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