与肥胖相关的高血压患者中的细胞因子和微生物群概况
María Magdalena Aguirre-García1, Amedeo Amedei2,3, Paulina Hernández-Ruiz1
1Unidad de Investigación UNAM-INC, División de Investigación, Facultad de Medicina, Universidad Nacional Autónoma de México, Instituto Nacional de Cardiología "Ignacio Chávez, Ciudad de México, Mexico.
Frontiers in cellular and infection microbiology
|January 31, 2024
概括
在墨西哥成年人中,与肥胖相关的高血压与不同的口腔和肠道细菌特征有关. 像Kluyvera这样的特定口腔细菌得到了丰富,而肠道微生物群显示出Firmicutes的优势,与炎症相关.
科学领域:
- 微生物组研究的研究.
- 心血管疾病是什么心血管疾病
- 炎症生物学 炎症生物学
背景情况:
- 系统性动脉高血压 (SAH) 是一个全球性的健康问题,在墨西哥普遍存在,增加心血管疾病的风险.
- 高血压与口腔和肠道微生物群的功能失调有关,包括减少有益的短链脂肪酸生产者.
- 肥胖会加剧高血压,这表明代谢状态,微生物群和血压之间的复杂相互作用.
研究的目的:
- 为了研究墨西哥患有与肥胖相关的高血压患者的细胞因子概况.
- 在这个患者群体中描述口腔和肠道微生物群的组成.
- 探索肥胖中微生物群变化,炎症和高血压之间的潜在联系.
主要方法:
- 一项横截面的观察性研究,涉及22名墨西哥超重和肥胖患者,他们被诊断患有初级高血压.
- 16S rRNA基因测序是在从supragingival牙斑和便样本中提取的DNA上进行的.
- 对13种关键细胞因子进行了量化,以评估系统性炎症.
主要成果:
- 口服微生物群分析显示,与超重患者相比,肥胖患者中*Kluyvera*属的显著丰富.
- 肠道微生物群主要由来自 *Firmicutes* 族的细菌组成.
- 在特定的细菌属和促炎性细胞因子之间观察到相关性.
结论:
- 这项研究提供了关于口腔和肠道微生物群在与肥胖相关的高血压中的复杂关系的初步见解.
- 研究结果表明,微生物失生症和系统性炎症在肥胖个体高血压病理生理学中可能发挥作用.
- 需要进一步的研究来阐明因果机制和治疗潜力.
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