心血管风险负担,痴呆风险和大脑结构成像标记:英国生物银行的一项研究
Yaying Cao1,2, Gaohong Zhu3, Chengwu Feng2
1Department of Food Nutrition and Health, School of Medicine and Health, Harbin Institute of Technology, Harbin, Heilongjiang, China.
高心血管风险负担增加了痴呆症的风险,包括阿尔茨海默氏症和血管痴呆症,在很大程度上独立于遗传. 这凸显了管理心脏健康对大脑健康的重要性.
科学领域:
- 神经科学是一个神经科学.
- 心脏病学 心脏病学
- 老年学是一门学科.
背景情况:
- 心血管风险负担与痴呆风险和大脑结构变化有关.
- 在这种关联中,遗传学和心血管疾病 (CVD) 的独立作用需要进一步研究.
研究的目的:
- 评估整体心血管风险负担与主要痴呆症亚型风险之间的关联.
- 探索遗传学和事件心血管疾病对这种关系的影响.
- 为了检查心血管风险对大脑结构体积的影响.
主要方法:
- 英国生物库对354,654名参与者 (平均年龄56.4岁) 进行了前性研究,他们没有心脏病和痴呆症.
- 使用弗雷明汉姆一般心血管风险评分 (FGCRS) 评估心血管风险.
- 对15,104名参与者的脑MRI数据进行了分析;通过住院病人和死亡登记册确定了痴呆症病例.
主要成果:
- 较高的FGCRS与所有原因,阿尔茨海默氏症和血管痴呆风险增加相关,独立于生活方式,临床因素和多基因风险评分 (PRS).
- 发生性中风和冠心病解释了14%的FGCRS-痴呆症相关性.
- 较高的FGCRS与增加的白质超强度和减少的灰色/皮质体积有关.
结论:
- 心血管风险负担与主要痴呆症亚型相关,独立于心血管疾病发病和遗传倾向.
- 管理心血管风险因素对于减轻痴呆风险至关重要.
- 研究结果强调了心血管健康与大脑结构完整性之间的联系.
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