过敏性鼻炎:通过创新诊断来定制免疫疗法
Bandar A Abushal1, Abdullah Bormah2, Malak Alghamdi3
1Department of Otolaryngology, Ministry of Health, Makkah, SAU.
Cureus
|January 31, 2024
概括
过敏性鼻炎 (AR) 诊断正在通过新的分子测试取得进展. 这些进展支持个性化免疫疗法,为这种慢性过敏状况提供有效的管理.
科学领域:
- 免疫学 免疫学 免疫学
- 过敏学 过敏学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 过敏性鼻炎 (AR) 是由IgE介导的过敏原反应引起的慢性疾病,通常与喘和结膜炎同时发生.
- 风险因素包括环境和遗传因素,导致显著的发病率和工作表现下降.
- 目前的诊断依赖于临床评估,并补充了皮肤刺伤测试 (SPT) 和鼻子过敏原挑战 (NAC) 等测试.
研究的目的:
- 为了提供对过敏性鼻炎的全面概述.
- 要突出AR的诊断方法的演变.
- 探索先进诊断和个性化治疗策略,特别是免疫治疗之间的联系.
主要方法:
- 对过敏性鼻炎的当前诊断方法的审查.
- 讨论传统方法 (临床病史,SPT,NAC,鼻腔细胞学).
- 探索先进的分子诊断模式 (基细胞激活试验-BAT,免疫固相过敏芯片-ISAC).
主要成果:
- AR诊断正在发展超越传统方法.
- 像BAT和ISAC这样的分子诊断提供了确认的见解.
- 免疫疗法在AR治疗中显示出有效性和轻微的副作用.
结论:
- 在AR诊断方面的进步正在为个性化治疗铺平道路.
- 免疫疗法正在成为AR的关键个性化方法.
- 弥合诊断和个性化治疗之间的差距对于有效的AR管理至关重要.
更多相关视频
06:08Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
Published on: September 22, 2023
1.7K
06:34A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
Published on: June 4, 2017
10.0K
相关概念视频
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
298
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
298
Asthma-IV: Diagnostic and Management
2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K
Allergic Reactions
27.4K
Overview
27.4K
Drugs Used in Lower Respiratory Disorders: Overview
442
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
442
