相关实验视频

Updated: Jul 4, 2025

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Published on: December 5, 2018

5-甲治疗抑制含有伪尤里丁的小RNA输出到细胞外囊中

Sherman Qu, Hannah Nelson, Xiao Liu

bioRxiv : the preprint server for biology

|January 31, 2024

概括

5-甲化疗改变了小RNA (sRNA) 在结直肠癌细胞中的输出和修饰. 这会影响RNA代谢和细胞通过细胞外囊泡 (EVs) 进行细胞通信.

科学领域:

分子生物学分子生物学
癌症研究癌症研究
生物化学生物化学

背景情况:

5-甲 (5-FU) 是一种长期用于结直肠癌 (CRC) 的化疗剂.
它的主要机制是抑制DNA合成,但它也影响RNA代谢.
小RNAs (sRNAs) 和细胞外囊泡 (EVs) 在细胞通信和基因调节中发挥作用.

结论:

5-FU暴露改变了与EV相关的sRNAs的表达,修饰和定位.
这些变化表明5-FU毒性影响基于RNA的细胞通信的新机制.
这些发现突显了sRNA修饰和EV出口在化疗反应中的作用.

更多相关视频

Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides

Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides

Published on: July 26, 2018

Extremely Rapid and Specific Metabolic Labelling of RNA In Vivo with 4-Thiouracil Ers4tU

Extremely Rapid and Specific Metabolic Labelling of RNA In Vivo with 4-Thiouracil Ers4tU

Published on: August 22, 2019

相关概念视频

Nuclear Export of mRNA

Nuclear Export of mRNA

Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...