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在病原体感染期间,肠道微生物组的碳和硫代谢支持沙门氏菌
bioRxiv : the preprint server for biology
|January 31, 2024
概括
沙门氏菌感染改变了肠道微生物群,减少了多样性,但增加了特定细菌的基因表达. 硫化合物在炎症的肠道中促进沙门氏菌的呼吸,提供治疗点.
科学领域:
- 微生物生态学 微生物生态学
- 病原体与宿主之间的相互作用
- 肠道微生物组研究研究
背景情况:
- 沙门氏菌 (Salmonella enterica serovar Typhimurium) 是一个严重的公共卫生威胁.
- 肠道微生物组在沙门氏菌感染中的作用尚未得到充分研究.
- 了解微生物相互作用对于沙门氏菌的殖民和感染至关重要.
结论:
- 多omics方法提供了一个更深入的了解病原生物组超出基于amplicon的研究.
- 特定的细菌种群和代谢途径代表了减轻沙门氏菌感染的潜在治疗点.
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