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激发性神经元中的质瘤诱导的变化被mTOR抑制逆转

Alexander R Goldberg1, Athanassios Dovas1, Daniela Torres1

  • 1Department of Pathology and Cell Biology, Irving Cancer Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA.

bioRxiv : the preprint server for biology
|January 31, 2024
PubMed
概括

抑制mTOR可逆转质瘤诱导的神经元变化,包括改变基因表达和活性,为脑瘤提供新的治疗途径.

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mTOR Signaling and Cancer Progression03:03

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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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