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Updated: Jul 4, 2025

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation
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Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation

Published on: June 26, 2013

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性别特定的机制是海马核-核 accumbens 突触的长期增强的基础

Ashley E Copenhaver, Tara A LeGates

    bioRxiv : the preprint server for biology
    |January 31, 2024
    PubMed
    概括

    雄性和雌性小鼠在海马-核 accumbens 途径中显示类似的长期增强 (LTP). 然而,不同的分子机制,涉及特定的离子通道和受体,是每个性别的突触可塑性的基础.

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    Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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    Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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