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Updated: Jun 24, 2026

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing
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Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

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nf-core/airrflow:一种适应性免疫受体谱系分析工作流程,采用Imcantation框架

Gisela Gabernet, Susanna Marquez, Robert Bjornson

    bioRxiv : the preprint server for biology
    |January 31, 2024
    PubMed
    概括

    我们开发了nf-core/airrflow,这是一个可扩展的工作流程,用于自适应性免疫受体列表测序 (AIRR-seq) 数据分析. 该工具增强了B细胞和T细胞受体序列的处理,用于免疫谱系研究.

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    Cells of the Innate Immune Response01:28

    Cells of the Innate Immune Response

    The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
    Phagocytes
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    Immune Surveillance by NK Cells and Phagocytes01:25

    Immune Surveillance by NK Cells and Phagocytes

    Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
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    NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
    Cells of the Adaptive Immune Response01:23

    Cells of the Adaptive Immune Response

    The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
    Antigens Involved in Adaptive Immunity01:26

    Antigens Involved in Adaptive Immunity

    An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
    Complete Antigens
    Complete antigens possess both immunogenicity and reactivity.
    Diversity of Antigen Receptors01:28

    Diversity of Antigen Receptors

    Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
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    T Cell Activation and Clonal Selection01:22

    T Cell Activation and Clonal Selection

    T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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