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Updated: Jul 4, 2025

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

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在小鼠心脏中,RORα对Ca _V 1.2表达的循环节调节

Estelle Personnic, Garance Gerard, Corinne Poilbout

bioRxiv : the preprint server for biology

|January 31, 2024

概括

这项研究揭示,L型通道 (CaV1.2) 在心脏中表现出日常节律调节,受到RORα昼夜基因的影响. 这一发现对于理解心脏功能和疾病至关重要.

科学领域:

心脏病学心脏病学
时间生物学时间生物学
分子生物学分子生物学

背景情况:

心脏生理表现出每天的振荡,包括与 (K +) 通道表达相关的腹腔再极化变化.
由Cacna1c基因编码的L型通道 (CaV1.2) 在这些昼夜变化中的作用仍然不清楚.

结论:

心脏CaV1.2和K+通道 (KV4.2/4.3) 的RORα依赖的节律调节在日常心脏功能中起着重要作用.
这些发现表明,这些发现可能对心脏病理学和心脏病中的昼夜节律扰乱产生潜在影响.

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Circadian Rhythms and Gene Regulation

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...