超越高血压:检查可变血压在认知和大脑结构中的作用
Cassandra Morrison1, Michael D Oliver2,3, Farooq Kamal4,5
1Department of Psychology, Carleton University, Ontario, Canada, K1S 5B6.
medRxiv : the preprint server for health sciences
|January 31, 2024
概括
可变血压 (BP) 在老年人中显著加快认知衰退和大脑结构变化. 管理波动的血压对于降低痴呆风险和保持认知功能至关重要.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 心血管健康 心血管健康
背景情况:
- 高血压是认知能力下降和痴呆症的已知危险因素.
- 血压变化的影响 (BP),以正常和高读数之间的波动为特征,对认知功能和大脑结构的影响仍然不清楚.
研究的目的:
- 研究可变血压对老年人认知衰退和大脑结构变化的影响.
主要方法:
- 长度队列研究利用来自拉什阿尔茨海默氏病中心研究资源共享中心 (RUSH) 和阿尔茨海默氏病神经成像计划 (ADNI) 的数据.
- 包括血压测量和认知/MRI数据的参与者,将他们分类为正常BP,高BP或可变BP组.
- 评估了纵向灰质体积,白质高强度 (WMH) 负担,认知测试得分和死后神经病理学.
主要成果:
- 患有可变血压的老年人表现出最高的认知衰退率,其次是高血压,然后是正常血压的人.
- 可变血压与灰色物质体积损失的增加和WMH负担的增加有关,与正常和高血压相比.
- 死后神经病理学显示,与正常血压组相比,可变血压和高血压组的严重程度增加.
结论:
- 变化的血压显著导致老年人认知能力下降和结构性脑损伤.
- 这些结构变化可能会降低对痴呆相关病理的恢复力,增加痴呆风险.
- 有效管理可变血压对于减轻认知衰退和潜在地减少老年人群中痴呆风险至关重要.
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