视网膜输入是维持神经元膜在腹侧生殖细胞核中的神经元膜所需的
bioRxiv : the preprint server for biology
|January 31, 2024
概括
视网膜输入对于小鼠腹侧生殖核 (vLGN) 层的初始发育并不必不可少. 然而,这些视网膜信号对于在出生后维持抑制神经元的层状组织至关重要.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 视觉系统研究 视觉系统研究
背景情况:
- 视网膜质细胞 (RGC) 轴突投射到像背侧生殖细胞核 (dLGN) 和腹侧生殖细胞核 (vLGN) 这样的thalamic核.
- 虽然已知RGC输入对DLGN发育有影响,但它们在vLGN发育中的作用,特别是具有明显GABAergic亚型和膜的外部vLGN (vLGNe),尚不清楚.
- 确切的发展时间表和RGC对vLGNe层形成和维护的必要性仍然不清楚.
研究的目的:
- 调查vLGNe层状形成和维护的发展时间表.
- 确定RGC输入是否影响vLGNe.内细胞特异性神经元膜的发展.
- 了解RGC输入在vLGNe组织中的作用的关键时期.
主要方法:
- 使用了小鼠模型,包括那些缺乏视网膜输入的模型 (突变小鼠).
- 在不同产后发育阶段检查了vLGNe的层状结构和GABAergic细胞分布.
- 野生型和突变型小鼠从出生到产后发育的第一周的相比层状组织.
主要成果:
- vLGNe 层在出生时或出生前被指定,独立于RGC输入.
- 缺少视网膜输入的突变小鼠在出生时显示GABAergic细胞的正常层状分布.
- 这些突变者的产后发育 (第一周后) 显示出抑制神经元的层状组织受损,vLGNe/vLGNi边界模糊.
结论:
- 在外部vLGN中,细胞类型特定的膜的初始形成是独立于视网膜质细胞输入的.
- 视网膜信号对于长期维持vLGNe内的抑制神经元的层状组织至关重要.
- 这项研究强调了视觉输入在维护出生后特定的乳头核结构完整性方面的关键作用.
相关概念视频
The Retina
69.1K
The retina is a layer of nervous tissue at the back of the eye that transduces light into neural signals. This process, called phototransduction, is carried out by rod and cone photoreceptor cells in the back of the retina.
69.1K
Anatomy of the Eyeball
7.1K
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
7.1K
Vision
53.4K
Vision is the result of light being detected and transduced into neural signals by the retina of the eye. This information is then further analyzed and interpreted by the brain. First, light enters the front of the eye and is focused by the cornea and lens onto the retina—a thin sheet of neural tissue lining the back of the eye. Because of refraction through the convex lens of the eye, images are projected onto the retina upside-down and reversed.
53.4K
Functional Brain Systems: Reticular Formation
1.9K
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
1.9K
Photoreceptors and Visual Pathways
6.0K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.0K
Diencephalon: Thalamus and Information Relay
1.6K
The thalamus, often called “the gateway to the cerebral cortex,” is vital in processing and directing sensory and motor signals throughout the brain. Almost all inputs destined for the cerebral cortex, except for olfactory signals, are relayed through the thalamus. The thalamus is a sophisticated relay station, channeling information from various brain regions to the cerebral cortex, as well as a filter, prioritizing certain signals over others based on current physiological...
1.6K


