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改变的IgG4抗体对重复的mRNA和蛋白质COVID疫苗的反应

Raj Kalkeri¹, Mingzhu Zhu¹, Shane Cloney-Clark¹

¹Novavax, Inc., Gaithersburg, MD, USA.

medRxiv : the preprint server for health sciences

|January 31, 2024

概括

与mRNA疫苗不同,Novavax NVX-CoV2373疫苗没有增加IgG4抗体或损害免疫功能. 它独特地促进了IgG3反应,增强了病毒中和能力.

科学领域:

免疫学免疫学免疫学
疫苗学疫苗学疫苗学

背景情况:

重复的mRNA SARS-CoV-2疫苗接种与增加的IgG4抗体和减少的Fcγ介导的效应因子功能相关,可能限制病毒控制.
了解不同SARS-CoV-2疫苗平台的免疫影响对于公共卫生战略至关重要.

研究的目的:

在重复接种NVX-CoV2373疫苗后,评估抗体反应,包括IgG子类和Fcγ效应器功能.
为了比较NVX-CoV2373的免疫特征与报告的mRNA疫苗反应.

主要方法:

量化抗尖峰总体IgG,IgG1,IgG2,IgG3和IgG4. 这三种抗尖峰抗体是IgG,IgG1,IgG2,IgG3和IgG4.
测量了抗体依赖细胞化 (ADCP),细胞毒性 (ADCC) 和补充沉积 (ADCD) 的替代标记物.
在接受重复NVX-CoV2373疫苗接种的个体中分析了反应.

主要成果:

接种NVX-CoV2373疫苗并没有显著增加高峰特异性IgG4水平.
没有观察到对Fcγ效应因子功能的替代物 (ADCP,ADCC,ADCD) 的负面影响.
重复的NVX-CoV2373疫苗接种独特地增强了IgG3反应,与强大的SARS-CoV-2中和相关.

结论:

与mRNA疫苗相比,NVX-CoV2373蛋白质疫苗产生了一个独特的免疫特征.
这种特征支持强大的Fcγ效应器功能和强大的中和抗体反应.
对疫苗诱导的免疫学多样性的进一步研究可以为未来的公共卫生政策提供信息.

关键词:

在 COVID-19 疫情中,在IgG4的基础上,IgG4 在NVX-CoV237373中.疫苗疫苗疫苗疫苗它们是mRNARNA.

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