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Updated: Jul 4, 2025

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
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Published on: April 4, 2025

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人类DNA聚合酶β的Fapy•dG复制的生物化学和结构特征

Shijun Gao, Peyton N Oden, Benjamin J Ryan

    bioRxiv : the preprint server for biology
    |January 31, 2024
    PubMed
    概括

    突变性DNA损伤Fapy•dG导致G→T和G→A突变. DNA聚合酶β (Pol β) 绕过Fapy•dG,但由Fapy•dG在原始终端的低效延伸,而不是Fapy•dGTP的结合,驱动其突变效应.

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