在中年绝经后的女性中,血清雌激醇水平和尾肌肉质量指数之间存在关联
Fang Jin1, Yan-Fei Wang1, Zhong-Xin Zhu2
1Department of Osteoporosis Care and Control, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou 311200, Zhejiang Province, China.
World journal of orthopedics
|January 31, 2024
概括
血清雌激醇水平显示了中年绝经后妇女与尾肌肉质量指数的反向U形关系. 低 Estradiol 与肌肉质量下降有关,强调其在维护骨肌肉方面的重要性.
科学领域:
- 内分泌学 在内分泌学.
- 老年学是一门学科.
- 骨肌肉生理学 骨肌肉生理学
背景情况:
- 关于更年期雌激素损失及其对骨肌肉质量的影响,存在相互矛盾的发现.
- 了解这种关系对于中年妇女的健康至关重要.
研究的目的:
- 调查中年绝经后妇女血清雌激素水平和尾肌肉质量指数 (ALMI) 之间的关联.
- 利用基于人口的数据进行可靠的分析.
主要方法:
- 来自国家健康和营养检查调查 (2013-2016) 的673名绝经后妇女 (40-59岁) 的分析.
- 使用了加权多变量线性回归和通用添加模型.
- 两部分线性回归确定了值效应.
主要成果:
- 在血清雌激醇 (E2) 水平和ALMI之间观察到积极的关联.
- 在血清E2.2的高四分位数中观察到更高的ALMI水平.
- 一个反转的U形曲线证明了这种关系,转折点为85 pg/mL血清E2.
结论:
- 在中年绝经后妇女的血清E2水平和ALMI之间存在一个反转的U形关系.
- 低血清E2水平与此生命阶段的肌肉质量损失有关.
- 这些发现强调了雌激醇在维持绝经后骨肌肉质量的作用.
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