在患有家族腺多重症的儿童中检查高部胃肠道的多负荷:是否需要?
Thomas Middleton1, Ian Sugarman2
1From the Sheffield Children's Hospital.
JPGN reports
|January 31, 2024
概括
患有家族性腺瘤多重症 (FAP) 的年轻患者在早期发展上部胃肠道 (GI) 多重症. 在儿科和年轻成人FAP患者中,建议与结肠镜一起进行早期上部肠道查.
科学领域:
- 胃肠病学 胃肠病学
- 儿科瘤学 儿科瘤学
- 遗传学 遗传学 是一个
背景情况:
- 家庭腺瘤多重症 (FAP) 患者容易患上具有恶性潜力的上部胃肠道 (GI) 息肉.
- 目前的国际指导方针建议在20多岁的FAP患者中启动上部肠道查.
- 在FAP患者中,上部肠道息肉的早期发展表明目前的查建议可能会被推迟.
研究的目的:
- 评估儿科和年轻成人FAP患者上部胃肠道息肉的发生率和特征.
- 为了确定这个人群中上部胃肠道息肉是否比目前的查指南建议的更早出现.
- 倡导在FAP患者早期进行上部胃肠道查.
主要方法:
- 一项前性研究进行了12年,记录了9-17岁的FAP患者的所有上部肠道内镜.
- 收集的数据包括多的位置,组织学和治疗.
- 在28名患者身上进行了48次食道胃管腺镜检查.
主要成果:
- 79%的患者 (22/28) 患有胃或十二指腺息肉;36% (10/28) 患有胃腺瘤.
- 29% (8/28) 的患者有非常多的多.
- 所有21名患有十二指腺息肉的患者都患有腺瘤;没有观察到恶性瘤,但有些需要干预.
结论:
- 年轻的FAP患者比以前想象的更早地发展上部肠道息肉.
- 目前针对FAP的上部肠道查指南可能需要修订,以包括更早的启动.
- 对于儿科和年轻成人FAP患者,上部消化道的查应与结肠镜同时开始.
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