研究趋势和TRPV1的前沿热点基于图书识别和可视化分析
Jingchun Zeng1, Yiqian Lu2, Hui Chu2
1Rehabilitation Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Heliyon
|January 31, 2024
概括
本文献分析揭示了短暂受体潜在类型1 (TRPV1) 研究的关键趋势. 最近的研究重点关注TRPV1的结构及其在癌症和神经退行等疾病中的作用.
科学领域:
- 神经科学研究主导了短暂受体潜在类型1 (TRPV1) 研究领域.
- 美国在出版物方面处于领先地位,加利福尼亚大学旧金山分校是中央机构.
背景情况:
- 暂时受体潜在类型1 (TRPV1) 是一个重要的非选择性阴离子通道.
- 自1997年克隆以来,TRPV1由于其多样化的激活机制,引起了大量研究兴趣.
研究的目的:
- 进行TRPV1研究的文献计量和可视化分析.
- 评估2002年至2022年间发表的TRPV1论文的主题趋势和知识结构.
主要方法:
- 利用了来自Web of Science核心集合的7413篇论文的图书识别和可视化分析.
- 使用VOSviewer和CiteSpace来分析作者,机构,国家,共同引用的参考文献和关键词.
主要成果:
- 确定美国是最多产的国家,UCSF是最核心的机构.
- 关键词分析显示,从一般的TRPV1研究转向了TRPV1结构和疾病.
- 最近的热点包括氧化应激,TRPV1结构,癌症和建模.
结论:
- TRPV1研究提供了关于疼痛,癌症和神经退行性疾病的见解.
- TRPV1激动剂和对抗剂在临床上越来越多地使用,针在炎症性疼痛中显示出有效性.
- TRPV1与内分泌大麻素系统和新型信号通路有关.
相关概念视频
01:43Thermosensation
30.4K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
30.4K
01:18Patch Clamp
5.5K
Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...
5.5K
01:25Aquaporins
4.9K
Aquaporins or AQPs are a family of integral membrane proteins whose primary function is to transport water, while some called aquaglyceroporins also transport glycerol. In addition, aquaporins have also been suspected to be involved in transporting volatile substances, such as carbon dioxide and ammonia, across membranes. Such AQPs that act as gas channels are often highly expressed in cells involved in the gaseous exchange, such as red blood cells, epithelial cells, and pulmonary capillaries.
4.9K
01:24Resting Membrane Potential
18.6K
The relative difference in electrical charge, or voltage, between the inside and the outside of a cell membrane, is called the membrane potential. It is generated by differences in permeability of the membrane to various ions and the concentrations of these ions across the membrane.
The Inside of a Neuron is More Negative
The membrane potential of a cell can be measured by inserting a microelectrode into a cell and comparing the charge to a reference electrode in the extracellular fluid. The...
The Inside of a Neuron is More Negative
The membrane potential of a cell can be measured by inserting a microelectrode into a cell and comparing the charge to a reference electrode in the extracellular fluid. The...
18.6K
01:31Action Potential
8.0K
Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they...
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they...
8.0K
01:24Non-gated Ion Channels
6.8K
Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
6.8K