核因子kappa B信号通路是纤维化的主要调节者
Na Ren1, Wen-Feng Wang2, Liang Zou3
1The First School of Clinical Medicine, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China.
Frontiers in pharmacology
|January 31, 2024
概括
向核因子kappa B (NF-ƙB) 途径对于治疗纤维化,急性损伤 (AKI) 和慢性病 (CKD) 的常见并发症至关重要. 这篇评论探讨了NF-ƙBB.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 纤维化是急性损伤 (AKI) 和慢性病 (CKD) 等疾病中病进展的标志,是由氧化应激和炎症驱动的.
- 核因子kappa B (NF-ƙB) 信号通路是关键的调解者,在有害的循环中将氧化应激和炎症联系起来,从而促进损伤.
研究的目的:
- 审查NF-ƙB信号通路在各种脏疾病中纤维化病原体中的作用.
- 讨论针对NF-qB途径的治疗策略,包括天然产品和非编码RNA,用于治疗纤维化.
主要方法:
- 对调查纤维化中NF-ƙB通路的研究进行文献综述.
- 对氧化应激,炎症和损伤中NF-kB激活之间的分子机制的分析.
- 针对NF-ƙB.B.的当前和潜在治疗干预措施的汇编.
主要成果:
- 过度活跃的NF-qB信号驱动免疫细胞的招募和激活,加剧环境中的炎症和氧化应激.
- NF-ƙB的激活会通过亡,亡和纤维化导致损伤,影响IgA脏病,糖尿病脏病和移植后并发症等疾病.
- 依赖NF-qB的非编码RNA是缓解炎和纤维化的有希望的治疗标.
结论:
- 针对NF-ƙB信号通路提供了一个合理和有效的治疗纤维化的策略.
- 治疗方法,包括天然产品和对NF-qB调节的非编码RNA的调制,具有通过纤维化特征的脏疾病的管理潜力.
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