石墨烯量子点:绿色合成,表征和抗氧化和抗菌潜力
Pooja Kadyan1, Ponnusamy Thillai Arasu2, Sudhir Kumar Kataria1
1Department of Zoology, Maharshi Dayanand University, Rohtak, Haryana, India.
International journal of biomaterials
|January 31, 2024
概括
来自M. indica叶的石墨烯量子点 (GQD) 的绿色合成显示出强大的抗氧化和抗菌活性. 这些新型的GQD为打击抗生素耐药微生物提供了有效的替代方案.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
- 生物技术是生物技术.
背景情况:
- 抗生素耐药性是一个日益严重的全球健康问题,需要开发新的抗菌剂.
- 新型纳米材料由于其独特的特性和增强的生物效能,提供了潜在的解决方案.
研究的目的:
- 使用绿色化学方法与M. indica叶子合成石墨烯量子点 (GQDs).
- 评估合成的GQDs的抗氧化和抗微生物特性.
主要方法:
- 绿色合成的GQDs使用M. indica的叶子提取物.
- 使用FTIR,XRD,SEM,TEM和UV-Vis光谱进行表征.
- 在体外抗氧化剂测试 (清除疗效,IC50) 和对细菌和真菌的抗微生物敏感性测试.
主要成果:
- 球形GQDs已经成功合成和表征.
- 与乙醇叶提取物相比,合成的GQDs表现出更高的抗氧化活性,由较低的IC50值表明.
- GQDs表现出显著的广泛的抗微生物活性,对抗格拉姆阳性细菌 (黄金杆菌,细菌细菌),格拉姆阴性细菌 (大肠杆菌, Pseudomonas aeruginosa),和真菌 (黑色菌, Aspergillus flavus).
结论:
- 绿色合成的GQD具有显著的抗氧化和抗微生物特性.
- 该机制涉及促进反应性氧物种 (ROS) 的产生.
- 这项研究提出了一种可持续和有效的方法,用于开发GQD作为对抗耐药微生物的潜在治疗剂.
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