在亚急性创伤性脊髓损伤中,细分的下伤口病理自发活动
Michael J Berger1,2,3, Adenike A Adewuyi4,5,6, Christopher Doherty3,7
1International Collaboration on Repair Discoveries (ICORD), Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Muscle & nerve
|January 31, 2024
概括
病理性自发活动 (PSA) 在脊髓损伤 (SCI) 水平以下的较低运动神经元 (LMN) 中很常见. 这一发现影响了宫SCI患者的神经转移候选和时间.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 脊髓损伤研究 脊髓损伤研究
背景情况:
- 在脊髓损伤 (SCI) 中心以下的下部运动神经元 (LMN) 状态尚不清楚.
- 了解LMN健康状况对于旨在恢复部SCI后上肢功能的神经移植手术至关重要.
研究的目的:
- 为了确定病理自发活动 (PSA) 的频率,在宫SCI水平和以下的低损伤性LMN中.
- 评估LMN健康状况,从尾部到SCI损伤.
主要方法:
- 用针电肌图分析了57名患有创伤性宫SCI的个体的91个四肢.
- 分析按损伤水平分层 (C4及以上,C5,C6-7).
- 在肌肉中进行PSA评估,肌肉由C5-T1神经根内化.
主要成果:
- 在所有低损伤段中观察到高频率的PSA.
- 测试的68.7%的四肢显示PSA在C8-T1神经根水平.
- 在C5级损伤的个体中,58.3%的C5-6肌肉表现出PSA.
结论:
- 这些发现表明LMN异常在SCI以下的高患病率.
- 这些结果对选择神经转移候选人具有重要意义.
- 了解PSA频率会影响神经转移干预的时间和捐赠神经的选择.
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