在创伤性脑损伤后的功能性发作中减少未切割的带完整性
Caroline G Byington1, Adam M Goodman1, Jane B Allendorfer1,2
1Department of Neurology, UAB Epilepsy Center, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Epilepsia
|January 31, 2024
概括
功能性 (FS) 与未切割 (UF) 中白质完整性降低有关,即使考虑到创伤性脑损伤 (TBI). 这项研究探讨了TBI患者和没有FS的UF连接性.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 精神病学是一个精神病学.
背景情况:
- 功能性 (FS) 与不良生命事件 (ALEs) 和精神病相关疾病有关,但其神经生物学基础尚未完全理解.
- 白质通道的未化囊 (UF) 之前已与FS.的病理生理学有关.
- 了解UF结构连接在FS中的作用,特别是在创伤性脑损伤 (TBI) 的背景下,至关重要.
研究的目的:
- 调查FS和并发性TBI (TBI+FS) 患者和仅TBI (TBI-only) 患者之间的UF结构连接的差异.
- 探索UF白质完整性与FS患者精神症状严重程度之间的关系.
- 为了确定UF连接差异是否在对TBI状态进行控制后仍然存在.
主要方法:
- 使用先进的扩散磁共振成像 (dMRI) 技术,包括扩散光谱成像 (DSI) 和q空间二元形重建 (QSDR).
- 通过使用分数异构性 (FA),辐射扩散性 (RD) 和精简计数以及它们的不对称性指数 (AIs) 来评估双边UF完整性.
- 仅TBI (N=46) 和TBI+FS (N=55) 组之间的FU完整性和精神症状严重程度 (抑郁,焦虑,PTSD) 的比较.
主要成果:
- 与只有TBI的参与者相比,患有TBI+FS的参与者在UF通道中表现出左半球FA和RD不对称指数 (AI) 的显著降低 (p < .05,FDR校正).
- TBI+FS患者报告了抑郁症,焦虑症和PTSD的症状严重程度更高 (所有p < .01).
- 在UF白质完整度测量和精神病症状严重程度之间没有发现显著的相关性 (所有p>0.05,FDR修正).
结论:
- 这项研究表明,在FS患者中,UF的白质健康状况降低,即使在控制TBI史时也是如此.
- 调查结果表明,前膜结构连接,特别是在FU内,可能有助于FS症状.
- 结果不支持UF连接作为FS中情绪或焦虑并发症的主要驱动因素,独立于TBI史.
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