宿主肠道微生物群的相互作用影响了大西洋养殖鱼的寄生虫感染
Jaelle C Brealey1, Miyako Kodama2, Jacob A Rasmussen2,3
1Department of Natural History, NTNU University Museum, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
mSystems
|January 31, 2024
概括
主体基因型和肠道微生物群相互作用,影响大西洋鱼生长和寄生虫感染. 寄生鱼的失生症部分取决于宿主遗传学,揭示了全基因学研究对宿主-寄生虫动态的重要性.
科学领域:
- 微生物组研究的研究.
- 主体-寄生虫相互作用
- 基因组学和转录基因组学
背景情况:
- 动物及其微生物群具有共同的进化历史,但影响表型的宿主基因型和微生物群相互作用尚未完全理解.
- 肠道寄生虫感染显著影响动物健康,但感染期间的全基因学观点尚未得到充分研究.
研究的目的:
- 通过全基因学方法研究宿主微生物群相互作用如何塑造养殖大西洋鱼 (Salmo salar) 的终身生长和寄生虫感染.
- 分析鱼肠道的多组数据,以了解宿主基因,肠道微生物组成和肠道感染之间的关系.
主要方法:
- 采用全基因学方法对460只养殖的大西洋鱼进行了测试,从肠道样本中生成了多基因学数据 (元基因学,转录学,代谢学).
- 分析的重点是关联宿主基因型,肠道微生物组成 (包括Mycoplasma和Vibrionaceae),以及自然肠道 cestode 感染的流行率 (82%).
主要成果:
- 一种特定的Mycoplasma菌株 (MAG01) 主导着健康的鱼肠道,而受感染的/较小的鱼则显示了肠道微生物多样性增加,具有潜在的毒性细菌.
- 宿管感染与长非编码RNA的宿主基因组变异以及鱼肠mRNA转录组和代谢组的协调变化有关.
- 在较小的寄生鱼中观察到肠道微生物群失生症,部分受宿主基因型的影响.
结论:
- 小型和/或寄生在大西洋鱼的肠道微生物群表现出失生症,受宿主基因型的影响.
- 通过整合宿主遗传和微生物群,全基因方法对了解宿主-寄生虫动态非常有价值.
- 这项研究提供了寄生虫相关失生症期间宿主基因对微生物群变化的影响的证据.
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