系统性硬化症与静脉血栓栓塞,肺栓塞和深静脉血栓症之间的关联:一个元分析
1Department of Rheumatology, Korea University Anam Hospital, Korea University College of Medicine, 73, Goryeodae-ro, Seongbuk-gu, 02841, Seoul, Korea (Republic of). lyhcgh@korea.ac.kr.
Zeitschrift fur Rheumatologie
|January 31, 2024
概括
系统性硬化症 (SSc) 显著增加了静脉血栓栓塞 (VTE) 的风险,包括深静脉血栓塞 (DVT) 和肺栓塞 (PE). 患有SSc的患者需要对这些严重的血管疾病进行警监测.
科学领域:
- 类风湿病学 类风湿病学
- 血管医学 血管医学
- 流行病学 流行病学
背景情况:
- 系统性硬化症 (SSc) 是一种复杂的自身免疫性疾病,影响连接组织.
- 在SSc和静脉血栓塞栓症 (VTE) 之间的关联需要进一步澄清.
- 了解SSc中的VTE风险对于患者管理至关重要.
研究的目的:
- 系统地分析和综合有关SSc和VTE之间的相关性发表的数据.
- 在SSc.患者中量化VTE,深静脉血栓塞 (DVT) 和肺栓塞 (PE) 的风险.
主要方法:
- 在MEDLINE,EMBASE和Cochrane数据库中进行了全面的文献搜索.
- 对符合条件的研究进行了元分析,以计算VTE,DVT和PE的相对风险 (RR).
- 六项涉及41,105名SSc患者的试验被纳入了元分析.
主要成果:
- 在统计学上,SSc与增加VTE风险之间存在显著的整体相关性 (RR 2.372).
- 在SSc与PE (RR 3.154) 和DVT (RR 5.190) 之间观察到显著的相关性.
- 小组分析表明,不同种族 (美国人,欧洲人,亚洲人) 之间存在强烈的相关性.
结论:
- 系统性硬化症与患有静脉瘤,心血管瘤和 PE 的风险大幅增加有关.
- 这些发现凸显了密切监测SSc患者VTE发育的关键需求.
- 积极的监测和管理策略对于SSc.患者至关重要.
相关概念视频
Overview of Systemic Veins
469
Systemic veins are crucial blood vessels that return deoxygenated blood from various body tissues back to the heart. There are three systemic veins that return deoxygenated blood to the heart, they are as follows.
The coronary sinus, the heart's principal vein, resides in the coronary sulcus on the heart's posterior aspect. This broad venous channel receives nearly all venous blood from the myocardium, the heart muscle. It is fed by three primary veins: the great cardiac vein, the...
The coronary sinus, the heart's principal vein, resides in the coronary sulcus on the heart's posterior aspect. This broad venous channel receives nearly all venous blood from the myocardium, the heart muscle. It is fed by three primary veins: the great cardiac vein, the...
469
Esophageal Varices-I: Introduction
140
Esophageal varices are dilated, tortuous veins which are found mainly in the submucosa of the lower esophagus but which may also appear higher up or extend into the stomach. They develop due to increased pressure in the portal venous system, often as a result of liver cirrhosis. This condition scars and damages the liver, impeding normal blood flow through the portal vein. To compensate, blood seeks alternative pathways, forming fragile new vessels (varices) in the esophagus and stomach. These...
140
Venous Return
4.3K
The circulatory system plays a crucial role in ensuring the optimal functioning of the human body. One of its critical components is venous return - the process that completes the blood circulation cycle. This article will delve into the concept of venous return, how it works, and its significance to our health.
What is Venous Return?
Venous return refers to the rate at which blood flows back to the heart from the body's peripheral veins. It's an integral part of the circulatory system...
What is Venous Return?
Venous return refers to the rate at which blood flows back to the heart from the body's peripheral veins. It's an integral part of the circulatory system...
4.3K
Anticoagulant Drugs: Low-Molecular-Weight Heparins
698
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
698
Overview of the Vascular System
2.8K
The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
2.8K
Disorders of Hemostasis
915
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
915


