相关实验视频
Updated: Jul 4, 2025

07:37
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
114
在风湿病学中对维生素B12缺乏症的新视角:基于病例的审查
Natalia Aleksandra Dułak1, Magdalena Rytlewska2, Marta Jaskólska2
1Department of Rheumatology, Clinical Immunology, Geriatrics and Internal Medicine, Medical University of Gdansk, Gdansk, Poland. nataliadulak96@gmail.com.
Rheumatology international
|January 31, 2024
概括
维生素B12缺乏在风湿性疾病中很常见,并且可以模仿症状. 在三名患者中,补充改善了神经病痛,抑郁和疲劳,这表明其更广泛的治疗潜力.
科学领域:
- 类风湿病学 类风湿病学
- 神经学 神经学
- 临床医学 临床医学
背景情况:
- 维生素B12 (科巴胺) 缺乏症经常在患有风湿性疾病的患者中观察到.
- 自免疫性疾病,包括恶性贫血,是已知的原因,但也可能出现其他自免疫性缺陷.
- 维生素B12度低的症状往往与风湿性疾病症状重叠,导致误诊.
研究的目的:
- 调查维生素B12补充对具有重叠症状的类风湿性疾病患者的影响.
- 审查当前关于科巴拉明在风湿病中的作用及其潜在治疗益处的文献.
- 在风湿病诊断中提倡早期评估维生素B12水平.
主要方法:
- 对三个患有神经病痛,抑郁症,疲劳和肌肉衰弱,归因于类风湿性疾病的患者的案例研究分析.
- 关于维生素B12在风湿病学中的科学文献的综述.
- 在补充维生素B12后,症状的缓解的临床观察.
主要成果:
- 在服用维生素B12补充剂后,三名患者在神经病痛,抑郁症,疲劳和肌肉虚弱方面经历了显著改善.
- 维生素B12治疗在治疗风湿性疾病中的疼痛和神经病变方面显示出潜在的有效性,即使没有检测到缺乏症.
- 维生素B12具有神经保护性,有利于治疗复杂的类风湿病.
结论:
- 在风湿病患者中,即使有非典型的表现,也应该考虑维生素B12缺乏.
- 哥巴胺补充剂可能在风湿病学中为疼痛和神经病变提供治疗效益.
- 建议对患有风湿性疾病的患者进行早期维生素B12评估和潜在的补充.
相关概念视频
Connective Tissue Cell Types
3.2K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
3.2K
Genome-wide Association Studies-GWAS
13.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.4K
Role of Vitamins in Maintaining Bone Health
3.3K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.3K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
334
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
334
Autoimmune Disorders
439
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
439
Inflammatory Bowel Disease IV: Pharmacological Management
127
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
127

