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致癌性口腔人类乳头瘤病毒清除模式超过10年

Gypsyamber D'Souza^1,2, Sakshi R Tewari¹, Tanya Troy^1,2

¹Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

|January 31, 2024

概括

持续的瘤性口腔HPV (oncHPV) 感染,特别是HPV16,显著增加了口腔癌的风险. 一半流行的oncHPV感染持续超过五年,突出需要更好的查和风险评估.

科学领域:

在瘤学瘤学.
病毒学病毒学
公共卫生公共卫生

背景情况:

目前口腔大癌查不足.
了解瘤性口腔HPV (oncHPV) 的自然史对于开发有效的查策略至关重要.
持续的cHPV感染是口腔大癌的前体.

研究的目的:

探索瘤性HPV清除的四种不同的定义.
了解长期持续的瘤性口腔HPV感染的自然史.
识别与HPV清除和持续相关的风险因素.

主要方法:

一项前性多中心队列研究跟踪了高达10年的艾滋病毒风险参与者.
每6-12个月收集口腔冲洗和嘴样本,并测试瘤性HPV.
使用了四种HPV清除定义:clear1,clear2,clear3连续阴性和clearlast (在最后两次访问中呈阴性).

主要成果:

对于保守的定义 (clear3,clearlast),oncHPV清除的中位时间超过2年,但对于宽松的定义 (clear1,clear2) 则低于1.2年.
普遍存在的ONCHPV感染的清除可能性低于事件感染.
年龄较大,男性性别,艾滋病毒感染者,以及普遍存在的ONCHPV与清除率降低有关. 13.8%的人患有常见的ONCHPV,其中47.5%持续≥5年.
两名口服HPV16的男性患上了口腔癌;许多口服HPV16的男性持续了≥5年.

结论:

大多数发生的Onc HPV感染相对较快地清除.
然而,很大一部分流行性ONCHPV感染持续超过5年,这表明口腔癌的风险增加.
持续的ONCHPV,特别是HPV16,在两次以上的访问表明癌症风险增加.

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