在非症状阿尔茨海默氏病前的表皮细胞和视网膜血管变化
Giulia Corradetti1,2, Deniz Oncel1, Shin Kadomoto1
1Doheny Eye Institute, Pasadena, California, United States.
Investigative ophthalmology & visual science
|January 31, 2024
概括
光学连贯断层扫描血管造影 (OCTA) 显示了认知健康个体具有病态脑脊液 (CSF) Aβ42/tau比率的视网膜血管显著变化,这表明早期阿尔茨海默病 (AD) 指标.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 生物标志物发现发现
背景情况:
- 阿尔茨海默病 (AD) 的发病过程涉及粉样β (Aβ42) 和陶的积累.
- 早期发现预症状AD对于及时干预至关重要.
- 大脑脊髓液 (CSF) 的Aβ42/tau比率是AD病理学的已知生物标志物.
研究的目的:
- 为了比较视网膜光连贯断层扫描血管学 (OCTA) 在认知健康 (CH) 个体与病态 (PAT) 与正常 (NAT) CSF Aβ42/tau比率.
- 为了调查潜在的视网膜血管变化,表明前症状阿尔茨海默病 (AD).
主要方法:
- 扫描来源的OCTA扫描是在23名CH受试者进行的,之前进行了CSF分析.
- 研究对象被分为CH-PAT (Aβ42/tau < 2.7132) 和CH-NAT (Aβ42/tau ≥ 2.7132) 组.
- 视网膜血管参数包括输液密度 (PD),血管长密度 (VLD),碎形尺寸 (FrD),状血管区域 (FAZ) 面积,以及胆囊细胞流量缺陷 (CCFD) 被量化.
主要成果:
- 与CH-NAT受试者相比,具有病态的CSF Aβ42 / tau比率 (CH-PAT) 的CH受试者在表面血管综合体 (SVC) 中显著减少了PD,VLD和FrD.
- CH-PAT对象还显示FAZ面积显著增加,CCFDs升高.
结论:
- 使用OCTA进行视网膜血管分析,揭示了认知健康的个体与预症状AD的生物标志物的SVC和choriocapillaris的显著变化.
- 这些OCTA指标可以作为早期AD检测的潜在生物标志物,反映神经退行过程.
- 需要进一步的纵向研究来证实OCTA在评估前症状AD时的有用性.
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