脂蛋白,功能指标和慢性病之间的关系:来自大型前性队列研究的证据
Yingxin Liu1, Ruoting Wang1, Shuai Li1
1Center for Clinical Epidemiology and Methodology, Guangdong Second Provincial General Hospital, Guangzhou, China.
JMIR public health and surveillance
|January 31, 2024
概括
升高的脂蛋白[Lp[a]与高的尿白蛋白与肌素比率 (UACR) 相结合,显著增加慢性病 (CKD) 的风险. 这突出了Lp (a) 作为潜在的CKD风险因素,特别是在UACR升高的个体中.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心血管医学 心血管医学
- 公共卫生 公共卫生
背景情况:
- 慢性病 (CKD) 是一个主要的全球健康问题.
- 脂蛋白 (Lp) 是已知的心血管风险因素,但其在CKD发展中的作用仍在争论中.
- 功能指标显示出与病风险的不同关联,即使在正常范围内.
研究的目的:
- 调查Lp(a) 和功能指标对一般人群中发生CKD风险的综合影响.
- 探索Lp(a) 与UACR (尿中白蛋白与肌素的比率) 或eGFR (估计的淋巴透率) 在CKD发展中的相互作用.
主要方法:
- 分析了329,415名没有先前CKD的英国生物库参与者.
- 基线Lp(a) 水平分为低 (<75nmol/L) 或高 (≥75nmol/L).
- 使用UACR和eGFR评估基线功能,使用多变量Cox回归模型进行分析.
主要成果:
- 在12年半的时间里,发生了6003起CKD事件.
- 高Lp(a) 和CKD风险之间没有显著的总体关联 (HR1.05,P=.16).
- 对于CKD风险,Lp(a) 和UACR (P=.04) 之间的显著相互作用. 高Lp(a) 与高正常UACR (≥10 mg/g) 显示增加了CKD风险 (HR1.32,P<.001).
结论:
- 关于CKD风险,Lp(a) 和UACR之间存在显著的相互作用.
- Lp (a) 可能有助于CKD风险,特别是在UACR升高的个体中.
- 结果强调了对Lp(a) 和UACR的综合评估,用于对一般人群进行CKD风险评估和预防.
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