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Updated: Jul 4, 2025

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
10:13

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Published on: May 6, 2019

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细胞内在的PD-L1剥离维持了效应器CD8+T细胞的反应,并促进了抗瘤T细胞治疗

Xinran Wang1, Lu Lu2, Xiaochuan Hong3

  • 1Department of Obstetrics and Gynecology, Shanghai Key Laboratory of Gynecologic Oncology, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.

Cell reports
|January 31, 2024
PubMed
概括

细胞内编程细胞死亡配体1 (PD-L1) 损害了癌症中治疗性CD8+T细胞功能. 破坏内在的PD-L1增强了抗瘤免疫力,提供了一种新的免疫治疗策略.

关键词:
CD8(+) T细胞分化的过程CP: 癌症 癌症 癌症CP: 免疫学 免疫学在PD-L1/PD-1中使用.收养的T细胞疗法瘤免疫力 免疫力

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