相关实验视频
Updated: Jul 4, 2025

Pseudofracture: An Acute Peripheral Tissue Trauma Model
Published on: April 18, 2011
在手术固定四肢骨折之前,皮肤消毒
, Sheila Sprague1, Gerard Slobogean1
1From the Division of Orthopedic Surgery, Department of Surgery (S.S., H.J., J.A.-A., J.L., D.P., S. Bzovsky, O.P.S., J.L.G., M.B.), and the Department of Health Research Methods, Evidence, and Impact (L.T., D.H.-A., G.G.), McMaster University, Hamilton Health Sciences Hospital, General Site (F.M.), and the Population Health Research Institute (P.J.D.), Hamilton, ON, and the Department of Orthopedic Surgery, University of British Columbia, Vancouver (D.V., K.L.A.) - all in Canada; the Center for Orthopedic Injury Research and Innovation, Department of Orthopedics, University of Maryland School of Medicine (G.S., N.N.O.), and the Division of Infectious Diseases (M.J.) and the Division of Orthopedic Traumatology, Department of Orthopedics (G.S., M.J.G., R.V.O.), R. Adams Cowley Shock Trauma Center, the Trauma Survivors Network (J.L.W.) and Patient Representative (D.M., J.E.P., J.F.), University of Maryland Baltimore, the University of Maryland School of Pharmacy (C.D.M.), the Departments of Epidemiology and Public Health (A.D.H., J.N.H., L.M.O.) and of Medicine (G.M.S.), University of Maryland School of Medicine, Baltimore, and the Division of Orthopedic Traumatology, Department of Orthopedics, University of Maryland Capital Region Health, Largo (T.J., H.K.D.) - all in Maryland; the Association of periOperative Registered Nurses, Denver (A.W.); the Department of Orthopedic Surgery, Inova Fairfax Medical Campus, Fairfax, VA (R.A.H., G.E.G.); the Department of Orthopedic Surgery and Rehabilitation, Wake Forest University School of Medicine, Winston-Salem (H.T.P., E.A.C., S. Babcock, J.J.H.), the Division of Orthopedic Trauma, Atrium Health, Charlotte (K.D.P., L.B.K., M.K.), and the Department of Orthopedic Surgery, Duke University, Durham (R.M.R.) - all in North Carolina; the Department of Orthopedic Surgery, MetroHealth Medical Center, Cleveland (N.M.R., C.A.M.); the Department of Orthopedic Surgery, University of Utah, Salt Lake City (T.F.H., L.S.M.); the Department of Orthopedic Surgery and Rehabilitation, University of Mississippi Medical Center, Jackson (P.F.B., J.M.); the Division of Orthopedic Surgery, Sanford Health USD Medical Center, Sioux Falls, SD (R.E.V.D.); the Division of Orthopedic Surgery, Northwest Texas Healthcare System, Amarillo (G.D.P.); the Department of Orthopedic Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH (I.L.G., G.C.); the Department of Orthopedics and Rehabilitation, University of Wisconsin, Madison (C.M.D., G.R.K.); the Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School (M.J.W., A.G.K.), Carl J. Shapiro Department of Orthopedic Surgery, Beth Israel Deaconess Medical Center (M.F.M.), and the Department of Orthopedic Surgery, Harvard Medical School (A. Alnasser) - all in Boston; the Department of Orthopedics, Miller School of Medicine, University of Miami, Miami (M.H.); the Division of Orthopedic Trauma, Department of Orthopedic Surgery, University of Pennsylvania, Philadelphia (S.M., D.J.D.); the Division of Orthopedic Trauma, Department of Orthopedic Surgery, Indiana University School of Medicine, Indianapolis (R.M.N., J.S.); Bryan Health, Lincoln, NE (A.N.S., S.F.S.); the Department of Orthopedic Surgery, Prisma Health-Upstate, Greenville, SC (K.J.J., S.L.T.); the Department of Orthopedic Surgery, University of California, San Francisco, San Francisco (M.T.M., A.M.), the Department of Orthopedic Surgery, Cedars-Sinai Medical Center (C.A.L., C.N.M.), the Department of Orthopedic Surgery, Keck School of Medicine of the University of Southern California (J.T.P.), and the Department of Orthopedic Surgery, UCLA (C.L.), Los Angeles, and the Department of Orthopedic Surgery, University of California, Irvine, Irvine (J.A.S., A. Amirhekmat) - all in California; the Department of Orthopedic Surgery, Brooke Army Medical Center (J.T.F., J.C.R.), and the Department of Orthopedic Surgery, San Antonio Military Medical Center (S.N.P.) - both in Fort Sam Houston, TX; the Department of Orthopedic Surgery and Sports Medicine, University of Cincinnati, Cincinnati (M.J.B.); the Department of Orthopedics, Warren Alpert Medical School, Brown University, Providence, RI (C.G.T.); the Department of Orthopedic Surgery, University of Missouri, Columbia (G.J.D.R.); Louisiana State University Health Sciences Center Orthopedics New Orleans, New Orleans (R.D.Z.); and the Department of Orthopedic Surgery, Landstuhl Regional Medical Center, Landstuhl, Germany (J.-C.G.D.).
对于关闭四肢骨折,与赫西丁葡萄糖酸盐相比,酒精中的发烯酸减少了手术部位感染. 开放骨折的结果与开放骨折的结果相似,表明含量.
科学领域:
- 整形外科手术 整形外科手术
- 预防传染病 预防传染病
- 临床试验 临床试验
背景情况:
- 关于预防手术部位感染 (SSI) 在四肢骨折修复中的皮肤防毒疗效,存在相互矛盾的证据.
- 手术前的皮肤准备对于最小化骨科手术期间的微生物污染至关重要.
研究的目的:
- 为了比较在酒精中的有效性和在酒精中的基酸在肢体骨折修复中的皮肤消毒剂的有效性.
- 确定不同消毒剂对SSI发病率和重复手术率的影响.
主要方法:
- 一个集群随机交叉试验,涉及美国和加拿大的25家医院.
- 医院被指派使用0.7%的瓦克里莱克斯在74%的异醇中或2%的氧氨酸葡萄酸盐在70%的异醇中用于手术前的消毒剂.
- 患有开放或关闭四肢骨折的患者被分别分析为主要结果 (SSIs) 和次要结果 (无计划的重新手术).
主要成果:
- 在封闭骨折队列 (6785名患者) 中,SSI发生在2.4%的瓦克里莱克斯患者和3.3%的赫西丁葡萄糖酸盐患者中 (OR,0.74;95% CI,0.55至1.00;P=0.049).
- 在开放骨折队列 (1700名患者) 中,SSI发生在6.5%的波克莱克斯患者中,而7.3%的赫西丁葡萄酸盐患者中 (OR,0.86;95% CI,0.58至1.27;P=0.45).
- 两个消毒剂组之间,计划外的重新手术,一年后的结果和不良事件的发生率相似.
结论:
- 与酒精中的酸相比,酒精中的酸与关闭四肢骨折患者手术部位感染的发病率较低.
- 在患有开放四肢骨折的患者中,两种消毒剂之间没有观察到SSI率的显著差异.
- 抗菌剂的选择可能会影响特定骨折类型的SSI率,需要在手术前方案中考虑.
相关概念视频
Hand hygiene
Hand washing...
Handwashing II: Pre-procedure and Initial Procedure Steps
The hand washing procedure itself includes the following steps. First, cover cuts, if any, on hands with a waterproof dressing. Cuts and abrasions can become contaminated with bacteria hindering the ability to clean the area thoroughly. In addition, repeated hand washing can worsen an injury. The nails must be short and clean, without nail...
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
One of the advantages of...
Handwashing III: During the Procedure and Post-Procedure Steps

