相关实验视频

Updated: Jul 4, 2025

Predictive Immune Modeling of Solid Tumors

Predictive Immune Modeling of Solid Tumors

Published on: February 25, 2020

基于细胞-细胞通信网络的可解释机器学习预测了癌症患者对免疫检查点抑制剂的反应

Juhun Lee¹, Donghyo Kim¹, JungHo Kong¹

¹Department of Life Sciences, Pohang University of Science and Technology, Pohang 790-784, Korea.

Science advances

|January 31, 2024

概括

本研究引入了一种机器学习模型,使用瘤数据的细胞-细胞通信网络来预测患者对免疫检查点抑制剂 (ICI) 的反应. 该模型确定了关键的沟通通路,改善了ICI治疗疗效的预测.

科学领域:

在瘤学瘤学.
计算生物学计算生物学
免疫学免疫学免疫学

背景情况:

免疫检查点抑制剂 (ICI) 已经改变了癌症治疗,但在许多患者中有效性有限.
目前用于预测ICI反应的生物标志物不足,需要改进预测工具.

研究的目的:

开发一种可解释的机器学习 (ML) 模型,使用患者特异的细胞-细胞通信网络 (CCN) 预测ICI疗效.
确定与ICI反应和抵抗相关的关键通信通路和分子参与者.

主要方法:

从批量瘤转录组中解码了患者特定的CCN.
在11个队列和4种癌症类型的700多名ICI治疗患者样本上训练了一种可解释的ML模型.
在黑色素瘤患者的单细胞水平上验证了关键发现.

主要成果:

该ML模型准确地预测了四种癌症类型的ICI疗效 (中位数AUROC:0.79).
确定免疫细胞化学反应对于ICI反应和结构性细胞生长因子通信对抗性至关重要.
确认了黑色素瘤单细胞数据中的关键通信通路和参与者.

结论:

使用CCN的基于网络的ML方法可以有效地预测ICI有效性.
这种方法提供了对ICI反应和耐药性的生物学机制的洞察.
这种方法有可能扩大ICI在癌症患者的临床益处.

更多相关视频

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...