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Updated: Jul 4, 2025

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
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Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

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功能化核酸N3Methyluridine和2'-O-Alkyl/2'-Fluoro-N3Methyluridine可以提高核酶抵抗力,同时保持双重几何

Avijit Sahoo1, Gourav Das1, Atanu Ghosh2

  • 1Department of Chemistry, Indian Institute of Technology Kharagpur, West Bengal 721302, India.

Bioorganic & medicinal chemistry
|January 31, 2024
PubMed
概括

改性尿素核酸 (2'-O-基/2'-F-m3U) 增强了对核酶的寡核酸稳定性. 这些修改表明,通过增加稳定性和类似药物的特性,有望改善反感性/siRNA疗法.

关键词:
外核酶是外核酶的一种.这是一种N(3) -methyluridine.核酶电阻 核酶电阻 核酶电阻核酸核酸是一种核酸.有氧核酸的部分.热稳定性 热稳定性

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