表面活性剂治疗先天性隔膜和胎镜内膜气管封闭症中的表面活性剂治疗
Y Deniz Sevilmis1, Oluyinka O Olutoye1, Sarah Peiffer1
1Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas.
The Journal of surgical research
|January 31, 2024
概括
在先天性隔膜 (CDH) 中使用表面活性剂可能对经过胎儿内膜气管封闭 (FETO) 的婴儿有益,显示出更好的生存率和没有增加的伤害.
科学领域:
- 新生儿医学 新生儿医学
- 儿科手术 儿科手术
- 肺部病理学 肺部病理学
背景情况:
- kongenital diaphragmatic hernia (CDH) 呈现出显著的肺部挑战. 这是一个非常重要的疾病.
- 表面活性剂在CDH中的作用是有争议的,特别是随着胎儿透视内膜气管封闭 (FETO) 的引入.
- FETO提高了生存率,但伴随着早产和潜在的表面活性剂缺乏等风险.
研究的目的:
- 为了评估表面活性剂在CDH婴儿中给予的特征和结果.
- 为了确定CDH中表面活性剂的潜在益处或风险,特别是那些接受过FETO的人.
主要方法:
- 单边CDH患者的回顾性队列审查 (2015-2022年).
- 收集的数据:人口统计,围产期成像,结果.
- 按表面活性剂使用和FETO历史分层;统计分析包括后勤回归.
主要成果:
- 105名患者,18%接受了FETO,24%接受了表面活性剂.
- 接受表面活性剂的患者的妊娠年龄较早,出生体重较低.
- 在非FETO CDH患者中,表面活性剂与更糟糕的结果相关;在FETO组中没有这种关联,表面活性剂接受者显示出更好的生存率和可比的结果.
- 接受表面活性剂的FETO患者有改善生存率和减少ECMO使用的趋势.
结论:
- 表面活性剂的使用与CDH患者的发病率或死亡率的增加无关.
- 表面活性剂可能为经过FETO的CDH患者提供好处.
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