热不燃烧香烟被动吸烟对儿童氧化应激,内皮和血小板功能的影响
Lorenzo Loffredo1, Roberto Carnevale2, Arianna Pannunzio1
1Department of Clinical, Internal, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Environmental pollution (Barking, Essex : 1987)
|January 31, 2024
概括
热不燃烧香烟 (HNBC) 和传统烟草 (TT) 香烟的被动吸烟显著损害了儿童的心血管健康. 这两种暴露都会增加氧化应激和血小板激活,同时降低内皮功能,HNBC和TT烟雾暴露之间没有显著差异.
科学领域:
- 环境健康 环境健康
- 心血管研究研究心血管研究
- 儿科健康 儿科健康
背景情况:
- 全球加热不燃烧香烟 (HNBC) 使用的增加需要了解其对健康的影响.
- 以前的研究将HNBC使用与心血管问题,如氧化应激和内皮功能障碍有关.
- 关于被动HNBC烟雾暴露对儿童健康的影响的数据有限.
研究的目的:
- 调查暴露在HNBC和传统烟草 (TT) 香烟的被动烟雾中的儿童的氧化应激,内皮功能和血小板功能.
- 为了比较被动HNBC烟雾暴露对健康的影响与儿童的TT香烟烟雾暴露.
- 确定生物标志物,预测暴露儿童的不良心血管结果.
主要方法:
- 78名儿童 (年龄在2-18岁) 被分为三个组:HNBC被动吸烟者 (n=26),TT卷烟暴露者 (n=26) 和未暴露的对照者 (n=26).
- 评估了氧化应激标志物 (sNOX2-dp,异素,H2O2,NO生物可用性),内皮功能 (手臂流媒介扩张 - FMD) 和血小板功能 (sCD40L,sP-selectin,T-TAS血栓形成).
主要成果:
- 与对照组相比,暴露于HNBC或TT香烟的被动烟的儿童显示氧化应激 (sNOX2-dp,异oprostanes,H2O2) 和血小板激活 (sCD40L,sP-selectin,血栓形成) 的标志物显著增加.
- 暴露的儿童表现出手臂口炎的减少和NO生物可用性受损.
- 在暴露于HNBC烟雾和TT烟雾的儿童之间,没有观察到测量参数的显著差异.
结论:
- 通过增加氧化应激和血小板激活,并损害内皮功能,HNBC和TT香烟的被动吸烟会对儿童的心血管健康产生不利影响.
- 生物标志物如NOX2,H2O2,异质和丁与暴露儿童的内皮功能障碍和氧化应激有关.
- 调查结果强调需要采取干预措施,减少儿童暴露在包括HNBC在内的所有来源的被动烟中.
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