长期风险的VTE在 Sarcoidosis:一个全国性的队列研究
Adelina Yafasova1, Emil L Fosbøl1, Finn Gustafsson1
1Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Chest
|January 31, 2024
概括
患有沙尔科病的患者长期患有静脉血栓塞栓症 (VTE) 的风险明显更高,包括肺栓塞和深静脉血栓症 (DVT). 这种增加的风险是显而易见的,即使考虑到其他健康状况和癌症史.
科学领域:
- 心血管医学 心血管医学
- 肺部医学 肺部医学
- 类风湿病学 类风湿病学
背景情况:
- 慢性炎症是静脉血栓塞栓症 (VTE) 的已知危险因素.
- 有限的数据存在VTE风险与其他炎症状况相比,在患有沙尔科毒症的患者.
- 肉病是一种炎症性疾病,对VTE风险的了解很少.
研究的目的:
- 为了确定患有沙尔科病的患者是否有长期风险增加的VTE.
- 为了比较肺栓塞和深静脉血栓塞 (DVT) 的发病率,在肉类发病患者与一般人群.
主要方法:
- 丹麦全国范围的登记册被用于识别被诊断患有沙尔科病的患者 (1996-2020年).
- 没有先前VTE的患者与基于年龄,性别和并发症的对照进行了1:4匹配.
- 主要结局是VTE的发生,随访时间长达8.8年.
主要成果:
- 与对照组 (1.6%) 相比,肉病患者 (n=14,742) 显示VTE的10年风险显著更高 (2.9%).
- 在沙尔科毒症组中,肺栓塞 (1.5%与0.7%) 和深血栓塞 (1.6%与1.0%) 的风险增加.
- 麻症在诊断后的第一年与VTE风险增加了4.94倍,在诊断后的第一年增加了1.65倍.
结论:
- 胰腺硬化症与VTE的长期风险相对较高.
- 升高的VTE风险持续超过了沙尔科毒症诊断后的最初一年.
- 这一发现凸显了在类型病的管理中考虑VTE风险的重要性.
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