用不同的交叉连接剂和热交叉连接修改的 κ-Carrageenan/sericin 聚合物矩阵:改善了 mefenamic 酸的释放特征
Wedja Timóteo Vieira1, Maria Vitória Silva Nicolini1, Meuris Gurgel Carlos da Silva1
1University of Campinas, School of Chemical Engineering, Albert Einstein Av. 500, Cidade Universitária "Zeferino Vaz", Campinas, SP 13083-852, Brazil.
International journal of biological macromolecules
|January 31, 2024
概括
这项研究开发了交联的k-carrageenan/sericin混合物,用于增强美胺酸 (MAC) 输送. 这种新的配方改善了药物加载和释放,为免费的MAC提供了更安全的替代品.
科学领域:
- 材料科学 材料科学 材料科学
- 制药科学 制药科学
- 生物技术是生物技术.
背景情况:
- 控制释放系统可以提高药物的有效性和患者的遵守性.
- 梅芬胺酸 (MAC) 是一种非类固醇抗炎药物,具有改善输送系统的潜力.
- 交叉连接的聚合物矩阵可以创建3D网络,以获得先进的材料特性.
研究的目的:
- 为了改善梅芬胺酸 (MAC) 的受控释放特征.
- 开发和表征 κ-卡拉基/氨酸交叉连接的混合物用于药物输送.
- 评估新型配方的胃阻力,药物释放动力学和生物相容性.
主要方法:
- 在 κ-carrageenan 和 sericin 的共价和热交联中.
- 使用FTIR,热重力测量分析和DSC进行交联混合物的表征.
- 在体外溶解测试以评估胃抵抗和药物释放概况.
- 对药物载荷,捕获效率和颗粒特性的分析.
- 使用 κ-Car/Ser/carboxymethylcellulose 配方进行体外细胞活性的研究.
主要成果:
- 获得了高的捕获效率 (94.11-104.25%) 和药物负载 (36.50-47.50%).
- 适当的颗粒大小 (1.34-1.57毫米),球形和粗的表面.
- 韦布尔模型表明药物通过放松,侵蚀和Fickian扩散释放.
- FTIR和TGA证实了材料的稳定性,没有MAC-聚合物相互作用.
- 在药物装载的珠子中,DSC显示出稳定的MAC特征.
- 与无细胞毒性MAC相比,交联混合物增强了细胞活力 (> 85%).
结论:
- 交叉连接的 κ-卡拉基/素混合物显示出对持续释放的美胺酸有前途的特性.
- 开发的配方提供了更好的药物输送与增强的生物相容性.
- 这种方法为抗炎药物提供了更安全,更有效的输送系统.
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