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口服固体制剂的体外释放和生物可访问性在动态胃肠道系统中模拟禁食和食状态:对甲福明化片的案例研究

Shilei Yang1, Zejun Hu1, Peng Wu2

  • 1Life Quality Engineering Interest Group, School of Chemical and Environmental Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu Province 215123, China; Xiao Dong Pro-health (Suzhou) Instrumentation Co Ltd, Suzhou, Jiangsu Province 215152, China.

International journal of pharmaceutics
|January 31, 2024
PubMed
概括

食物显著影响口服药片中甲福明的释放,持续释放 (SR) 配方的食物效应比立即释放 (IR) 配方更小. 动态人类胃肠 (DHSI-IV) 系统准确地预测了这些体内行为.

关键词:
动态溶解是一种动态溶解.食物对食物的影响在体外的胃肠道系统.甲福林化片片 甲福林化片口服用药的剂型是口服的预测等离子体度的预测

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