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繁殖小鼠中的筑巢:宏观和微观环境的影响
Luciana Cintra1,2, Sandra Regina Alexandre-Ribeiro3, Julia Trindade Xavier Teixeira4
1Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, Brazil.
Laboratory animals
|January 31, 2024
概括
实验室小鼠的筑巢质量可以表明它们的行为和幸福感的变化. 湿度和子变化等因素显著影响巢穴得分,突出了它们对动物福利的重要性.
科学领域:
- 实验室动物科学 动物科学
- 动物福利研究 动物福利研究
- 动物行为研究研究动物行为研究.
背景情况:
- 严格控制住房条件对于实验室小鼠至关重要,以尽量减少实验结果的变化.
- 提供筑巢材料可以提高实验室小鼠的活动和生存率.
- 筑巢是一种自然的行为,可能反映出小鼠的健康和福祉.
研究的目的:
- 评估筑巢质量是否可以作为检测老鼠交配行为变化的指标.
- 评估环境和遗传因素对受控动物设施中的质量的影响.
主要方法:
- 来自847个子 (三个遗传背景:129,B6,BALB/c) 的相关的筑巢得分,具有18个预定义的变量.
- 利用描述性数据分析,对应分析和顺序物流模型来评估质量.
- 评估了不同性别和一夫一妻制小鼠对遗传背景的巢穴得分.
主要成果:
- 在巢穴质量和巢穴位置之间观察到强烈的相关性.
- 巢建得分受到湿度,遗传背景,子变化和幼存在 (数量和年龄) 的显著影响.
- 子的变化和相对湿度被确定为对筑巢质量产生负面影响的关键因素.
结论:
- 巢建得分提供了一种简单的,最少的侵入性方法来评估实验室老鼠的健康和福祉.
- 巢穴质量评估可以支持动物设施的有效管理实践.
- 在长期研究中,观察员的培训和经验对于一致的巢评分评估很重要.
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