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在类风湿性关节炎的临床前阶段,肠道微生物群和肠道炎症
Benoît Thomas P Gilbert1,2, Raul Yhossef Tito Tadeo3,4, Celine Lamacchia5,2
1Division of Rheumatology, HUG, Geneva, Switzerland benoit.gilbert@unige.ch.
RMD open
|January 31, 2024
概括
这项研究发现,在临床前类风湿性关节炎 (RA) 阶段,肠道微生物组概况没有显著差异. 在不同组中,Prevotellaceae的丰富程度没有差异,这表明肠道微生物组可能不是 RA 发展的可靠早期生物标志物.
科学领域:
- 微生物组研究的研究.
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
背景情况:
- 肠道微生物组的改变,特别是Prevotellaceae,与类风湿性关节炎 (RA) 和其临床前阶段有关.
- 了解这些微生物关联对于早期RA检测和干预至关重要.
研究的目的:
- 在风湿性关节炎 (RA) 临床前阶段的个体中调查定量微生物组概况.
- 识别潜在的肠道微生物生物标志物与风险人群的早期RA发展相关.
主要方法:
- 使用16S测序对来自371名患者的便样本进行定量微生物组分析,分为四个临床前RA类别.
- 分析包括DADA2管道,席尔瓦数据库,PERMANOVA,威尔科森,克鲁斯卡尔-瓦利斯和阿尔德克斯2.
- 用ELISA测量了便中的calprotectin水平.
主要成果:
- 在临床前RA阶段 (PERMANOVA p > 0.5) 中,没有观察到量化或相对微生物组特征的显著差异.
- 在定义的临床前RA组之间,Prevotellaceae的丰度没有显著的差异.
- 便中的calprotectin水平在研究组之间没有差异.
结论:
- 这项研究没有确定与临床前类风湿性关节炎 (RA) 相关的独特微生物组配置文件.
- 包括Prevotellaceae在内的肠道微生物组似乎不是RA早期,临床前阶段的可靠指标.
- 之前报告的关联在具有更明显的临床表型的子组中仅适度观察到.
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