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大规模蛋白质组学识别出新生物标记物和大动脉狭窄的循环风险因素

Khaled Shelbaya¹, Victoria Arthur¹, Yimin Yang¹

¹Brigham and Women's Hospital, Boston, Massachusetts, USA.

Journal of the American College of Cardiology

|January 31, 2024

概括

这项研究确定了矩阵金属蛋白酶12 (MMP12) 作为大动脉狭窄 (AS) 风险的潜在生物标志物. 补充C1q瘤坏死因子相关蛋白1 (C1QTNF1) 显示为预防AS进展的目标.

科学领域:

心血管研究研究心血管研究
蛋白质组学是指蛋白质组学.
生物标志物发现发现

背景情况:

关于大动脉狭窄 (AS) 风险因素的数据有限.
血蛋白质组为发现新生物标志物和理解AS的致病机制提供了一个有希望的途径.
识别新的生物标志物对于AS的早期检测和干预至关重要.

研究的目的:

发现与大动脉狭窄 (AS) 相关的新型血蛋白生物标志物.
识别具有与AS潜在因果关联的蛋白质.
探索特定蛋白质在AS进展和化中的作用.

主要方法:

使用 SomaScan 试验测量了 4,877 个血蛋白在社区动脉样硬化风险 (ARIC) 研究参与者.
分析了蛋白质与大动脉 (AV) 峰值速度 (AVmax),无维指数和与AV相关的住院病例之间的关联.
使用多变量回归,门德尔随机化,心脏CT用于化,以及在扩展的AV组织中进行基因表达分析.

主要成果:

52种蛋白质的截面与AVmax,无维指数和发生的AV相关住院有关.
矩阵金属蛋白酶12 (MMP12) 和补充C1q瘤缩因子相关蛋白1 (C1QTNF1) 在一个独立的队列中与中度/严重的AS显著相关.
MMP12与增加的AVmax,AV化和性AV组织中的更高表达相关;C1QTNF1显示了对AS和AVmax的潜在因果作用.

结论:

矩阵金属蛋白酶12 (MMP12) 被确定为大动脉狭窄 (AS) 风险的潜在新型循环生物标志物.
补充C1q瘤坏死因子相关蛋白1 (C1QTNF1) 成为防止AS进展的新假定治疗标.
这些发现有助于了解AS的发病过程,并为临床管理提供新的途径.

关键词:

大动脉狭窄症 (大动脉狭窄症)超声心电图 (Echocardiography) 是一种心声回声仪.流行病学流行病学蛋白质组学蛋白质组学

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