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Updated: Jul 4, 2025

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杂的Hsp70调节器YM-1诱导BRD4的降解

Yugo Mishima1, Shusuke Tomoshige1, Shinichi Sato1,2

  • 1Graduate School of Life Sciences, Tohoku University.

Chemical & pharmaceutical bulletin
|January 31, 2024
PubMed
概括

YM-1是一种热冲击70kDa蛋白 (Hsp70) 调节器,通过促进含有4 (BRD4) 的原体的降解,触发癌细胞死亡. 这种机制涉及Hsp70,CHIP和BRD4无处不在,导致癌基因表达减少.

关键词:
在YM-1中,YM-1是第一个.含有4 (BRD4) 的原蛋白.癌症治疗 治疗 治疗 癌症热冲击70kDa蛋白质 (Hsp70) 的热冲击蛋白质降解 蛋白质降解

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