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有效调节听觉处理的PARVALBUMIN神经元在状体的尾部

Xuan Li^1,2,3,4,5, Jiapeng You^1,2,3,4,5, Yidi Pan^1,2,3,4

¹Guangdong-Hong Kong-Macaoh Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China.

The Journal of neuroscience : the official journal of the Society for Neuroscience

|January 31, 2024

概括

条形体 (TS) 尾部的帕尔瓦胺 (PV) 内神经元调节小鼠的听觉反应. 这些神经元虽然数量较少,但它们的投射范围广泛,并影响听觉处理和行为.

科学领域:

神经科学是一个神经科学.
审计系统研究审计系统研究
抑制性内部神经元功能抑制性内部神经元功能

背景情况:

听觉皮层 (AC) 中的帕瓦胺 (PV) 内神经元对于听觉处理至关重要.
此外,PV内部神经元在状体 (TS) 的尾部也是关键的,这是一个下降的听觉通路.
在听觉处理中,TS PV内部神经元的确切功能尚不清楚.

研究的目的:

为了研究TS PV内部神经元的形态和功能性质.
确定TS PV内部神经元在听觉处理中的作用及其对棘状投射神经元 (SPN) 的影响.
探索TS PV内部神经元对听觉相关行为的贡献.

主要方法:

在雄性和雌性小鼠中进行形态分析和切片电生理学.
记录TS PV内部神经元和SPN的听觉反应.
光遗传学操纵,以评估TS PV内部神经元的功能影响.

主要成果:

TS PV 内神经元较少,但比AC PV 内神经元具有更长的投射,有效抑制SPNs.
TS PV 内神经元接收大量的听觉输入,特别是来自中间生殖器体 (MGB),其反应与AC PV 内神经元相似.
光遗传激活或抑制TS PV内部神经元双向改变SPN听觉反应.

结论:

在TS中的PV内部神经元在调节听觉处理方面发挥着重要作用.
TS PV 内神经元对于调节SPN的听觉反应至关重要.
这些发现表明,TS PV内部神经元在与听觉相关的行为中起着关键作用.

关键词:

审计审计审计审计审计审计审计审计审计审计这是一种双向调制.在内部神经元中,parvalbumin存在.有刺的投影神经元神经元.条形体的尾巴条形体的尾巴

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