在活跃与稳定的牛皮病变中对神经性炎症的排泄物光效应
Marwa S El-Mesidy1, Yomna A Metwally2, Zeinab A Nour3
1Dermatology Department, Kasr Al Ainy Faculty of Medicine, Cairo University, Cairo, Egypt. Marwa.elmesidy@kasralainy.edu.eg.
Lasers in medical science
|January 31, 2024
概括
极致光疗有效地通过降低物质P及其受体水平来降低牛皮的严重程度和症状. 这种治疗对活跃和稳定的斑块性牛皮有好处,可能通过减少神经性炎症.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
背景情况:
- 牛皮的发病包括由T辅助细胞17和物质P (SP) 介导的神经性炎症.
- 极致光疗是一种诱导T细胞亡的牛皮治疗方法.
研究的目的:
- 为了评估催化剂光对活跃和稳定的牛皮的影响.
- 为了研究治疗后物质P (SP) 和其受体 (NK-1R) 水平的变化.
主要方法:
- 包括27名稳定患者,27名活跃的牛皮患者和10名对照患者.
- 临床严重程度 (PSI,VAS) 和组织SP / NK-1R水平在43名患者的9次催化剂光疗程之前和之后被测量.
主要成果:
- 在所有患者中,除光疗显著降低了牛皮的严重程度 (PSI) 和 (VAS).
- 治疗前的SP水平在牛皮患者中高于对照组.
- 在治疗后,SP和NK-1R水平在稳定和活跃的牛皮群体中显著下降.
结论:
- 排泄物光疗对于稳定和活跃的斑块牛皮是有效的.
- 治疗的好处可能来自通过降低SP和NK-1R水平改善神经性炎症.
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