脑下垂体低性炎与多性炎 (GPA) 结合的颗粒性炎症:一个病例系列
Majid Alameri1, Abdulla Alnuaimi1, Niamh M Martin1
1Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK.
Pituitary
|January 31, 2024
概括
带有多炎 (GPA) 的粒状瘤可以影响垂体腺,导致炎症和质量效应. 用Rituximab (RTX) 进行免疫抑制疗法为与GPA相关的低体质炎提供了安全有效的治疗方法.
科学领域:
- 内分泌学 在内分泌学.
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
背景情况:
- 带有多炎 (GPA) 的颗粒瘤病是一种罕见的全身性血管炎.
- 脑下垂体参与GPA (下垂体炎) 是不常见的,影响大约1%的患者.
- 由GPA诱导的低血性炎通常表现为 pituitary 质量效应和 arginine 血管压素缺乏.
研究的目的:
- 在GPA中描述垂体瘤的临床范围.
- 评估Rituximab (RTX) 在治疗与GPA相关的低血压炎的疗效和安全性.
主要方法:
- 三名患有GPA和hypophysitis的患者的回顾性病例系列.
- 治疗涉及初始高剂量的葡萄皮质激素,随后是RTX的维持免疫抑制.
- 监测了临床结果和副作用.
主要成果:
- 这三名患者都在接受RTX治疗后实现了低血清炎的缓解.
- 作为维持治疗,RTX被用6个月一次的输液给药.
- 治疗方案耐受性良好,没有显著的不良事件.
结论:
- 利图西马布是一种有效和安全的治疗选择,用于与GPA相关的低血压炎.
- 这种免疫抑制方法可以在GPA患者中成功管理垂体功能障碍.
- 对GPA的垂体特异性指导方针进行进一步的研究是有必要的.
相关概念视频
Pulmonary Hypertension: Classification and Pathogenesis
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
There are various classifications for PH, each relating to different underlying causes and also...
Acute Pyelonephritis II: Diagnostic Studies and Management
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Graves' Disease I: Introduction
Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
Graves Disease II: Pathophysiology
Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...


