来自微生物来源的天然和人工基产品
Jianzhao Qi1,2,3, Shi-Jie Kang4, Ling Zhao5
1Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, 712100, China. qjz@nwafu.edu.cn.
Natural products and bioprospecting
|January 31, 2024
概括
本综述总结了126种微生物化天然产品,重点是化二烯和化三烯. 它强调需要对这些化合物及其基转移酶进行进一步的研究,以发现药物.
科学领域:
- 自然产品化学 自然产品化学
- 微生物学 微生物学
- 生物化学 生物化学
背景情况:
- 糖基化是一种常见的后修改,显著影响自然产品的多样性和活性.
- 化是一种罕见的糖化形式,微生物衍生的化天然产品仍未得到充分探索.
- 本次审查重点关注来自微生物的纤维化天然产品,这些产品具有独特的结构和有益的活动.
研究的目的:
- 提供微生物衍生型化天然产品的综合摘要.
- 突出不同类型的化化合物的结构多样性和流行程度.
- 强调西洛转移酶在天然产品生物合成和药物发现中的重要性.
主要方法:
- 已知微生物衍生的化天然产品的文献综述和汇编.
- 基于结构类别的化合物的分类 (例如,西洛西尔-乙烯二烯,西洛西三烯).
- 对化化合物的结构多样性和来源 (细菌与真菌) 的分析.
主要成果:
- 这里介绍了126种微生物衍生的化天然产品的综合目录.
- 克西洛基亚二烯和克西洛化三烯是最丰富的类.
- 与真菌对应物相比,细菌化化合物具有较少定义的结构配置.
- 克西洛转移酶EriJ的表征扩大了已知的克西洛基亚二烯的多样性.
结论:
- 微生物衍生的化天然产品是药物发现和合成化学的宝贵资源.
- 进一步探索这些化合物和开发新型的基转移酶是有必要的.
- 基因组测序的进步很可能会导致发现更多的生物活性化化合物及其生物合成途径.
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