缺少sub-Tenon的triamcinolone乙胺的风险因素对于乌维性黄斑胀的风险因素
Amit K Reddy1, Jennifer L Patnaik2, Alan G Palestine2
1Department of Ophthalmology, University of Colorado School of Medicine, 1675 Aurora Court, F731, Aurora, CO, 80045, USA. amit.reddy@cuanschutz.edu.
Journal of ophthalmic inflammation and infection
|January 31, 2024
概括
下一个词:sub-tenon
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 炎症性眼睛疾病 炎症性眼睛疾病
背景情况:
- 亚泰农的三氨乙化物 (STA) 提供了一个更低成本,更低风险的替代品,用于内皮质类固醇,用于脑膜斑点 (ME).
- 确定STA治疗失败的预测因素对于优化患者护理和避免不必要的干预至关重要.
- 了解哪些患者不太可能对STA做出反应,可以引导决策转向更强效的疗法.
研究的目的:
- 为了确定与治疗失败相关的风险因素,Sub-Tenon的三氨乙胺 (STA) 在患有乌维性黄斑 (ME) 的患者中.
- 确定预测指标,表明什么时候STA可能不足以管理脑膜炎性ME.
主要方法:
- 一项回顾性队列研究分析了来自131名在2013年至2022年期间因脑膜炎性ME接受STA治疗的患者的180只眼睛.
- 乌维特性ME是通过光学连贯断层扫描 (OCT) 或光素血管扫描 (FA) 诊断的.
- 治疗失败被定义为持续或恶化的ME需要在12周内进行额外的治疗. 评估了基线中央子场厚度 (CST) 和其他临床因素.
主要成果:
- 总体而言,23.3%的眼睛 (42/180) 经历了STA治疗失败.
- 在OCT上较高的基线中央子场厚度 (CST) 与STA失效的可能性增加显著相关 (OR 1.17每30μm增加,P=0.016).
- 在多变量分析中,其他因素如年龄,种族,性别,糖尿病,脑膜炎分类和先前的治疗没有显示出显著的关联.
结论:
- 亚泰农的三氨乙化物 (STA) 是一种有效的治疗乌维性斑点 (ME),特别是在较低基线中央子场厚度 (CST) 的情况下.
- 临床医生可能会考虑将STA作为轻度紫外线性ME的初始治疗方法,因为与视窗内选择相比,STA的成本和安全性较好.
- 较高的基线CST可能表明需要STA以外的替代或更积极的治疗策略.
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